Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy

Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy

ObjectiveHere we looked for possible mechanisms regulating the progression of type 1 diabetes mellitus (T1DM). In this disease, autoaggressive T cells (T conventional cells, Tconvs) not properly controlled by T regulatory cells (Tregs) destroy pancreatic islets.Research design and methodsWe compared...

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Bibliographic Details
Main Authors: Mateusz Gliwiński, Dorota Iwaszkiewicz-Grześ, Anna Wołoszyn-Durkiewicz, Monika Tarnowska, Magdalena Żalińska, Matylda Hennig, Hanna Zielińska, Anna Dukat-Mazurek, Joanna Zielkowska-Dębska, Maciej Zieliński, Anna Jaźwińska-Curyłło, Radosław Owczuk, Przemysława Jarosz-Chobot, Artur Bossowski, Agnieszka Szadkowska, Natalia Marek-Trzonkowska, Grażyna Moszkowska, Janusz Siebert, Małgorzata Myśliwiec, Piotr Trzonkowski
Format: Article
Language:English
Published: BMJ Publishing Group 2020-04-01
Series:BMJ Open Diabetes Research & Care
Online Access:https://drc.bmj.com/content/8/1/e000873.full

Internet

https://drc.bmj.com/content/8/1/e000873.full

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