A Specific Inhibitor of TGF-β Receptor Kinase, SB-431542, as a Potent Antitumor Agent for Human Cancers

Small molecule inhibitors of signaling pathways have proven to be extremely useful for the development of therapeutic strategies for human cancers. Blocking the tumor-promoting effects of transforming growth factor-β (TGF-β) in advanced stage carcinogenesis provides a potentially interesting drug t...

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Bibliographic Details
Main Authors: Sunil K. Halder, R. Daniel Beauchamp, Pran K. Datta
Format: Article
Language:English
Published: Elsevier 2005-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800570