The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection

The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection

Abstract Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory m...

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Bibliographic Details
Main Authors: William Foulsham, Sharad K. Mittal, Takeshi Nakao, Giulia Coco, Yukako Taketani, Sunil K. Chauhan, Reza Dana
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-44973-y

Internet

https://doi.org/10.1038/s41598-019-44973-y

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