Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress and Apoptosis

Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress and Apoptosis

Histone deacetylase 6 (HDAC6) contributed to the pathogenesis of rhabdomyolysis-induced acute kidney injury (AKI) and selective inhibition of HDAC6 activity may be a promising strategy for the treatment of AKI. Compound 23BB as a highly selective HDAC6 inhibitor was designed, synthesized by our lab...

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Bibliographic Details
Main Authors: Yuying Feng, Rongshuang Huang, Fan Guo, Yan Liang, Jin Xiang, Song Lei, Min Shi, Lingzhi Li, Jing Liu, Yanhuan Feng, Liang Ma, Ping Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
rhabdomyolysis
acute kidney injury
histone deacetylase 6 inhibitor
endoplasmic reticulum stress
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00274/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00274/full

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