Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

<p>Abstract</p> <p>Background</p> <p>Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic function. Since specific pharmac...

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Bibliographic Details
Main Authors: Mastaitis Jason W, Mizuno Tooru M, Makimura Hideo, Agami Reuven, Mobbs Charles V
Format: Article
Language:English
Published: BMC 2002-11-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/3/18

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