Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells.

Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells.

<h4>Background</h4>Mesenchymal and amoeboid movements are two important mechanisms adopted by cancer cells to invade the surrounding environment. Mesenchymal movement depends on extracellular matrix protease activity, amoeboid movement on the RhoA-dependent kinase ROCK. Cancer cells can...

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Main Authors: Cristina Belgiovine, Roberta Frapolli, Katiuscia Bonezzi, Ilaria Chiodi, Francesco Favero, Maurizia Mello-Grand, Angelo P Dei Tos, Elena Giulotto, Giulia Taraboletti, Maurizio D'Incalci, Chiara Mondello
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21209796/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21209796/?tool=EBI

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