Host-Derived Microvesicles Carrying Bacterial Pore-Forming Toxins Deliver Signals to Macrophages: A Novel Mechanism of Shaping Immune Responses

Host-Derived Microvesicles Carrying Bacterial Pore-Forming Toxins Deliver Signals to Macrophages: A Novel Mechanism of Shaping Immune Responses

Bacterial infectious diseases are a leading cause of death. Pore-forming toxins (PFTs) are important virulence factors of Gram-positive pathogens, which disrupt the plasma membrane of host cells and can lead to cell death. Yet, host defense and cell membrane repair mechanisms have been identified: i...

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Bibliographic Details
Main Authors: René Köffel, Heidi Wolfmeier, Yu Larpin, Hervé Besançon, Roman Schoenauer, Viktoria S. Babiychuk, Patrick Drücker, Thomas Pabst, Timothy J. Mitchell, Eduard B. Babiychuk, Annette Draeger
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
macrophage polarization
microvesicles
liposomes
bacterial pore-forming toxins
host-defense
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01688/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01688/full

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