The Impact of Mevastatin on HCV Replication and Autophagy of Non-Transformed HCV Replicon Hepatocytes Is Influenced by the Extracellular Lipid Uptake

The Impact of Mevastatin on HCV Replication and Autophagy of Non-Transformed HCV Replicon Hepatocytes Is Influenced by the Extracellular Lipid Uptake

Statins efficiently inhibit cholesterol synthesis by blocking 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the mevalonate pathway. However, the effect of statins on intracellular cholesterol is partially counterbalanced by a consequent increased uptake of extracellular lipid sources. Hepatitis...

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Bibliographic Details
Main Authors: Tiziana Vescovo, Giulia Refolo, Matteo Ciancio Manuelli, Giuseppe Tisone, Mauro Piacentini, Gian Maria Fimia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
hepatitis C virus
cholesterol
autophagy
RNA replication
lipid uptake
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00718/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00718/full

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