LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration

LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration

Summary: Liver kinase B1 (LKB1) is involved in several biological processes and is a key regulator of hepatic metabolism and polarity. Here, we demonstrate that the master kinase LKB1 plays a dual role in liver regeneration, independently of its major target, AMP-activated protein kinase (AMPK). We...

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Bibliographic Details
Main Authors: Vanessa Maillet, Nadia Boussetta, Jocelyne Leclerc, Véronique Fauveau, Marc Foretz, Benoit Viollet, Jean-Pierre Couty, Séverine Celton-Morizur, Christine Perret, Chantal Desdouets
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
LKB1
hepatocytes
liver regeneration
EGFR
mitosis fidelity
microtubule spindle
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301505

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http://www.sciencedirect.com/science/article/pii/S2211124718301505

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