The Signature Amino Acid Residue Serine 31 of HIV-1C Tat Potentiates an Activated Phenotype in Endothelial Cells

The Signature Amino Acid Residue Serine 31 of HIV-1C Tat Potentiates an Activated Phenotype in Endothelial Cells

The natural cysteine to serine variation at position 31 of Tat in HIV-1C disrupts the dicysteine motif attenuating the chemokine function of Tat. We ask if there exists a trade-off in terms of a gain of function for HIV-1C Tat due to this natural variation. We constructed two Tat-expression vectors...

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Bibliographic Details
Main Authors: Malini Menon, Roli Budhwar, Rohit Nandan Shukla, Kiran Bankar, Madavan Vasudevan, Udaykumar Ranga
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
HIV-1C
genetic subtypes
Tat
signature amino acid residue
CCL2
endothelial cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.529614/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.529614/full

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