Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer’s Disease: Computational Refining and Biochemical Evaluation

Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer’s Disease: Computational Refining and Biochemical Evaluation

Amyloid precursor protein (APP), upon proteolytic degradation, forms aggregates of amyloid β (Aβ) and plaques in the brain, which are pathological hallmarks of Alzheimer’s disease (AD). Cathepsin B is a cysteine protease enzyme that catalyzes the proteolytic degradation of APP in the brain. Thus, ca...

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Bibliographic Details
Main Authors: Nitin Chitranshi, Ashutosh Kumar, Samran Sheriff, Veer Gupta, Angela Godinez, Danit Saks, Soumalya Sarkar, Ting Shen, Mehdi Mirzaei, Devaraj Basavarajappa, Morteza Abyadeh, Sachin K. Singh, Kamal Dua, Kam Y. J. Zhang, Stuart L. Graham, Vivek Gupta
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
Alzheimer’s disease
cathepsin B
3D pharmacophore
virtual screening
docking
molecular dynamics
Online Access:https://www.mdpi.com/2073-4409/10/8/1946

Internet

https://www.mdpi.com/2073-4409/10/8/1946

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