Selumetinib Activity in Thyroid Cancer Cells: Modulation of Sodium Iodide Symporter and Associated miRNAs

Selumetinib Activity in Thyroid Cancer Cells: Modulation of Sodium Iodide Symporter and Associated miRNAs

Background: The MEK (mitogen-activated protein kinase)–inhibitor selumetinib led to increased radioiodine uptake and retention in a subgroup of patients suffering from radioiodine refractory differentiated thyroid cancer (RR-DTC). We aimed to analyse the effect of selumetinib on the expres...

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Bibliographic Details
Main Authors: Sabine Wächter, Annette Wunderlich, Brandon H. Greene, Silvia Roth, Moritz Elxnat, Sebastian A. Fellinger, Frederik A. Verburg, Markus Luster, Detlef K. Bartsch, Pietro Di Fazio
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
radioiodine refractory differentiated thyroid cancer
miRNAs
MEK (mitogen-activated protein kinase kinase) inhibitor
Online Access:http://www.mdpi.com/1422-0067/19/7/2077

Internet

http://www.mdpi.com/1422-0067/19/7/2077

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