Stereotactic Body Radiotherapy Is Effective in Modifying the Tumor Genome and Tumor Immune Microenvironment in Non-Small Cell Lung Cancer or Lung Metastatic Carcinoma

Stereotactic Body Radiotherapy Is Effective in Modifying the Tumor Genome and Tumor Immune Microenvironment in Non-Small Cell Lung Cancer or Lung Metastatic Carcinoma

Background and PurposeTo directly reveal the change in genome mutation, RNA transcript of tumor cells, and tumor microenvironment (TME) after stereotactic body radiotherapy (SBRT) in paired human lung tumor specimens.Materials and MethodsPaired tumor samples were collected from 10 patients with non-...

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Bibliographic Details
Main Authors: Pu Zhou, Diangang Chen, Bo Zhu, Wei Chen, Qichao Xie, Yali Wang, Qiulin Tan, Bibo Yuan, Xuejiao Zuo, Changlin Huang, Hongfan Zhu, Guanghui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
stereotactic body radiotherapy
tumor microenvironment
tumor-infiltrating immune cells
T-cell receptor
whole-exome sequencing
RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.594212/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.594212/full

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