The Role of Multiscale Protein Dynamics in Antigen Presentation and T Lymphocyte Recognition

T lymphocytes are stimulated when they recognize short peptides bound to class I proteins of the major histocompatibility complex (MHC) protein, as peptide–MHC complexes. Due to the diversity in T-cell receptor (TCR) molecules together with both the peptides and MHC proteins they bind to, it has bee...

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Bibliographic Details
Main Authors: R. Charlotte Eccleston, Shunzhou Wan, Neil Dalchau, Peter V. Coveney
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00797/full