A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts

Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA polymerase II (RNA Pol II). While four viral immediate early proteins (ICP4, ICP0, ICP27, and ICP22) function in some capacity in viral transcription, the mechanism by which ICP22 functions remains unclear. We observed that the FAC...

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Bibliographic Details
Main Authors: Hannah L. Fox, Jill A. Dembowski, Neal A. DeLuca, Michael J. Imperiale
Format: Article
Language:English
Published: American Society for Microbiology 2017-06-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/3/e00745-17