Structure–Activity Relationship of RGD-Containing Cyclic Octapeptide and αvβ3 Integrin Allows for Rapid Identification of a New Peptide Antagonist

Structure–Activity Relationship of RGD-Containing Cyclic Octapeptide and αvβ3 Integrin Allows for Rapid Identification of a New Peptide Antagonist

The αvβ3 integrin, a receptor for many extracellular matrix proteins with RGD-sequence motif, is involved in multiple physiological processes and highly expressed in tumor cells, therefore making it a target for cancer therapy and tumor imaging. Several RGD-containing cyclic octapeptide (named LXW a...

Full description

Bibliographic Details
Main Authors: Aaron Silva, Wenwu Xiao, Yan Wang, Wei Wang, Heng Wei Chang, James B. Ames, Kit S. Lam, Yonghong Zhang
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
integrin αvβ3 antagonists
RGD peptides
structure–activity relationship
in silico screening
in vitro binding
Online Access:https://www.mdpi.com/1422-0067/21/9/3076

Internet

https://www.mdpi.com/1422-0067/21/9/3076

Similar Items