The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of <i>Aspergillus fumigatus</i>

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of <i>Aspergillus fumigatus</i>

The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH). The pyrimidines uracil, thymine and cytosine are the building blocks of DNA and RNA; thus, inhibition of their synthesis i...

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Bibliographic Details
Main Authors: Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E.M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Journal of Fungi
Subjects:
antifungal drugs
olorofim
DHODH
pyrimidines
<i>Aspergillus fumigatus</i>
fungal cell morphogenesis
Online Access:https://www.mdpi.com/2309-608X/6/2/47

Internet

https://www.mdpi.com/2309-608X/6/2/47

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