Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats

Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats

Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available. Hypoxia-inducible factor 1α is a critical molecule targeting several genes associated with ischemia-hypoxia damage and ang...

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Bibliographic Details
Main Authors: Tao Wang, Li-Ni Zeng, Zhe Zhu, Yu-Hui Wang, Lu Ding, Wei-Bin Luo, Xiao-Min Zhang, Zhi-Wei He, Hong-Fu Wu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; peripheral nerve injury; brachial plexus avulsion; hypoxia; ischemia; hypoxia-inducible factor 1α overexpression; pluronic F-127; motor neurons; axonal regeneration; angiogenesis; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=6;spage=1069;epage=1078;aulast=Wang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=6;spage=1069;epage=1078;aulast=Wang

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