Modulation of Mitochondrial Permeability Transition Pore Affects Multidrug Resistance in Human Hepatocellular Carcinoma Cells

<p>Multidrug resistance (MDR) is a critical problem in the chemotherapy of cancers. Human hepatocellular carcinoma (HCC) responds poorly to chemotherapy owing to its potent MDR. Chemotherapeutic drugs primarily act by inducing apoptosis of cancer cells, and defects in apoptosis may result in M...

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Bibliographic Details
Main Author: Xianlong Ling, Yuan Zhou, Shi-Wei Li, Bin Yan, Lei Wen
Format: Article
Language:English
Published: Ivyspring International Publisher 2010-01-01
Series:International Journal of Biological Sciences
Online Access:http://www.biolsci.org/v06p0773.htm