STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1

STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1

Show other versions (1)

BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11–13, and the BRCT domain. The BRCA1 RING domain is responsible for the E3 ubiquitin ligase activity o...

Full description

Bibliographic Details
Main Authors: Serena L. Clark, Ana M. Rodriguez, Russell R. Snyder, Gary D.V. Hankins, Darren Boehning
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Apoptosis
Bcl-2
Bax
BH3 domain
Apaf-1
Apoptosome
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014601070

Internet

http://www.sciencedirect.com/science/article/pii/S2001037014601070

Similar Items