Parkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency

Parkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency

Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases with TDP-43 mislocalization and aggregation. Genetic forms of FTLD and ALS are caused by pathogenic variants in various genes, such as PGRN (progranulin). To date, depletion of parkin E3 u...

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Bibliographic Details
Main Authors: Katarzyna Gaweda-Walerych, Dawid Walerych, Mariusz Berdyński, Emanuele Buratti, Cezary Zekanowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
frontotemporal lobar degeneration
progranulin deficiency
parkin
TDP-43
primary fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.676478/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.676478/full

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