Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity. In agreement with this, NRP1+ ILC3s are mainly lo...

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Bibliographic Details
Main Authors: Medya Mara Shikhagaie, Åsa K. Björklund, Jenny Mjösberg, Jonas S. Erjefält, Anne S. Cornelissen, Xavier Romero Ros, Suzanne M. Bal, Jasper J. Koning, Reina E. Mebius, Michiko Mori, Melanie Bruchard, Bianca Blom, Hergen Spits
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
neuropilin-1
NRP1
lymphoid tissue inducer cells
LTi
human innate lymphoid cells 3
ILC3
high endothelial venues
HEVs
vascular endothelial growth factor A
VEGF-A
chemotaxis
smoke-induced pulmonary lymphoid aggregates
LA
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301201

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http://www.sciencedirect.com/science/article/pii/S2211124717301201

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