High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas

High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas

Molecular mechanisms of lower-grade (II–III) diffuse gliomas (LGG) are still poorly understood, mainly because of their heterogeneity. They split into astrocytoma- (IDH-A) and oligodendroglioma-like (IDH-O) tumors both carrying mutations(s) at the isocitrate dehydrogenase (IDH) gene and into IDH wil...

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Bibliographic Details
Main Authors: Edith Willscher, Lydia Hopp, Markus Kreuz, Maria Schmidt, Siras Hakobyan, Arsen Arakelyan, Bettina Hentschel, David T. W. Jones, Stefan M. Pfister, Markus Loeffler, Henry Loeffler-Wirth, Hans Binder
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
grade II–IV gliomas
gene expression
DNA methylation
tumor heterogeneity
molecular subtypes
tumor evolution
Online Access:https://www.mdpi.com/2072-6694/13/13/3198

Internet

https://www.mdpi.com/2072-6694/13/13/3198

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