TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition

TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition

Background/Aims: Hypoxia is an environmental factor that aggravates liver fibrosis. HIF1α activates hepatic stellate cells (HSCs) and increases transforming growth factor-β (TGF-β) signaling and the epithelial mesenchymal transition (EMT), accelerating the progression of fibrosis. We evaluated the a...

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Bibliographic Details
Main Authors: Min-Jin Kim, Sang-A Park, Chun Hwa Kim, So-Yeon Park, Jung-Shin Kim, Dae-Kee Kim, Jeong-Seok Nam, Yhun Yhong Sheen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cholestatic liver injury
Hepatic stellate cell
TGF-β
HIF1α
Epithelial mesenchymal transition
EW-7197
Online Access:http://www.karger.com/Article/FullText/438651

Internet

http://www.karger.com/Article/FullText/438651

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