Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer’s Disease

Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer’s Disease

The major genetic risk for late onset Alzheimer’s disease has been associated with the presence of APOE4 alleles. However, the impact of different APOE alleles on the brain aging trajectory, and how they interact with the brain local environment in a sex specific manner is not entirely clear. We sou...

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Bibliographic Details
Main Authors: Alexandra Badea, Wenlin Wu, Jordan Shuff, Michele Wang, Robert J. Anderson, Yi Qi, G. Allan Johnson, Joan G. Wilson, Serge Koudoro, Eleftherios Garyfallidis, Carol A. Colton, David B. Dunson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Neuroinformatics
Subjects:
mouse model
Alzheimer’s disease
neurodegeneration
magnetic resonance imaging
tractography
tract based analysis
Online Access:https://www.frontiersin.org/article/10.3389/fninf.2019.00072/full

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https://www.frontiersin.org/article/10.3389/fninf.2019.00072/full

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