Influence of statin treatment on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites in patients after coronary angiography/angioplasty

Influence of statin treatment on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites in patients after coronary angiography/angioplasty

Possible interaction between clopidogrel and CYP3A4-metabolised atorvastatin or non-CYP3A4-metabolised rosuvastatin was investigated based on pharmacokinetic parameters of clopidogrel and its metabolites as well as the platelet reactivity test in patients undergoing coronary angiography/angioplasty....

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Bibliographic Details
Main Authors: Marta Karaźniewicz-Łada, Janusz Rzeźniczak, Franciszek Główka, Adriana Gumienna, Filip Dolatowski, Marek Słomczyński, Paweł Burchardt
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Atorvastatin
Clopidogrel thiol metabolite
Drug interaction
Platelet inhibition
Rosuvastatin
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219307255

Internet

http://www.sciencedirect.com/science/article/pii/S0753332219307255

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