Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross between two inbred strains. We re-genotyped a pr...

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Bibliographic Details
Main Authors: Xinzhu Zhou, Celine L. St. Pierre, Natalia M. Gonzales, Jennifer Zou, Riyan Cheng, Apurva S. Chitre, Greta Sokoloff, Abraham A. Palmer
Format: Article
Language:English
Published: Oxford University Press 2020-03-01
Series:G3: Genes, Genomes, Genetics
Subjects:
gwas
mouse genetics
replication
multiparent advanced generation inter-cross (magic)
multiparental
populations
mpp
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400763

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.400763

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