DNA methylome signatures of prenatal exposure to synthetic glucocorticoids in hippocampus and peripheral whole blood of female guinea pigs in early life

Abstract Synthetic glucocorticoids (sGC) are administered to women at risk of preterm delivery, approximately 10% of all pregnancies. In animal models, offspring exposed to elevated glucocorticoids, either by administration of sGC or endogenous glucocorticoids as a result of maternal stress, show in...

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Bibliographic Details
Main Authors: Aya Sasaki, Margaret E. Eng, Abigail H. Lee, Alisa Kostaki, Stephen G. Matthews
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-01186-6