Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer

Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer

Objective: Patients with cancer pain are highly dependent on morphine analgesia, but studies have shown a negative correlation between morphine demand and patient outcomes. The long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide (M3G) levels. Hence, the effects o...

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Bibliographic Details
Main Authors: Kaiyuan Wang, Jian Wang, Ting Liu, Wenwen Yu, Nan Dong, Chen Zhang, Wenbin Xia, Feng Wei, Lili Yang, Xiubao Ren
Format: Article
Language:English
Published: China Anti-Cancer Association 2021-02-01
Series:Cancer Biology & Medicine
Subjects:
non-small cell lung cancer
tlr4
pd-l1
morphine-3-glucuronide
immune escape
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1777

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1777

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