CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere

CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere

<b> </b>The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. However, the precise mechanisms of depositio...

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Bibliographic Details
Main Authors: Yohei Niikura, Risa Kitagawa, Katsumi Kitagawa
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
CENP-A
centromere identity
centromere
CUL4A-RBX1- COPS8 E3 ligase
dimerization
epigenetics
kinetochore
lysine 124 (K124), neocentromere
ubiquitylation
Online Access:https://www.mdpi.com/1420-3049/24/3/402

Internet

https://www.mdpi.com/1420-3049/24/3/402

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