Lys 199 mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists

Lys 199 mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists

Many slow dissociating (insurmountable) non-peptide angiotensin type 1 receptor (AT 1 ) antagonists contain, besides the acidic biphenyltetrazole substructure of losartan, a second acidic group to stabilise antagonist-receptor complexes. To investigate the involved basic amino-acids of the human AT...

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Bibliographic Details
Main Authors: Frederik LP Fierens, Patrick ML Vanderheyden, Zsuzsanna Gáborik, Tam Le Minh, Jean-Paul De Backer, László Hunyady, Adriaan Ijzerman, Georges Vauquelin
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2000-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.3317/jraas.2000.044

Internet

https://doi.org/10.3317/jraas.2000.044

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