Local Clonal Diversification and Dissemination of B Lymphocytes in the Human Bronchial Mucosa

Local Clonal Diversification and Dissemination of B Lymphocytes in the Human Bronchial Mucosa

The efficacy of the adaptive humoral immune response likely requires diverse, yet focused regional B cell antibody production throughout the body. Here we address, in the first study of its kind, the B cell repertoire in the bronchial mucosa, an important barrier to antigens inhaled from the atmosph...

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Bibliographic Details
Main Authors: Line Ohm-Laursen, Hailong Meng, Jessica Chen, Julian Q. Zhou, Chris J. Corrigan, Hannah J. Gould, Steven H. Kleinstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
asthma
B-cell antibody repertoire
bronchial mucosa
clonal dissemination
cell trafficking
next generation sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01976/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01976/full

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