Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology

Abstract Synaptic dysfunction and disconnectivity are core deficits in Alzheimer’s disease (AD), preceding clear changes in histopathology and cognitive functioning. Here, the early and late effects of tau pathology induction on functional network connectivity were investigated in P301L mice. Multic...

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Bibliographic Details
Main Authors: A. Ahnaou, D. Moechars, L. Raeymaekers, R. Biermans, N. V. Manyakov, A. Bottelbergs, C. Wintmolders, K. Van Kolen, T. Van De Casteele, J. A. Kemp, W. H. Drinkenburg
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-13839-6