Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency.

Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency.

The transcription factor Lmx1b is essential for the differentiation and survival of central serotonergic (5-HTergic) neurons during embryonic development. However, the role of Lmx1b in adult 5-HTergic neurons is unknown. We used an inducible Cre-LoxP system to selectively inactivate Lmx1b expression...

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Bibliographic Details
Main Authors: Ning-Ning Song, Jian-Bo Xiu, Ying Huang, Jia-Yin Chen, Lei Zhang, Lise Gutknecht, Klaus Peter Lesch, He Li, Yu-Qiang Ding
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3016403?pdf=render

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http://europepmc.org/articles/PMC3016403?pdf=render

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