Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.

Bibliographic Details
Main Authors:	Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A. Lashuel
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01575-4

id	doaj-a9accbe2206844e88e73f54fa7b62a03
record_format	Article
spelling	doaj-a9accbe2206844e88e73f54fa7b62a032021-05-11T07:51:19ZengNature Publishing GroupNature Communications2041-17232017-11-018111610.1038/s41467-017-01575-4Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexesNadine Ait-Bouziad0Guohua Lv1Anne-Laure Mahul-Mellier2Shifeng Xiao3Gizem Zorludemir4David Eliezer5Thomas Walz6Hilal A. Lashuel7Laboratory of Molecular and Chemical Biology of Neurodegeneration, Station 19, Ecole Polytechnique Fédérale de LausanneDepartment of Biochemistry and Program in Structural Biology, Weill Cornell MedicineLaboratory of Molecular and Chemical Biology of Neurodegeneration, Station 19, Ecole Polytechnique Fédérale de LausanneDepartment of Biochemistry and Program in Structural Biology, Weill Cornell MedicineLaboratory of Molecular and Chemical Biology of Neurodegeneration, Station 19, Ecole Polytechnique Fédérale de LausanneDepartment of Biochemistry and Program in Structural Biology, Weill Cornell MedicineLaboratory of Molecular Electron Microscopy, Rockefeller UniversityLaboratory of Molecular and Chemical Biology of Neurodegeneration, Station 19, Ecole Polytechnique Fédérale de LausanneThe Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.https://doi.org/10.1038/s41467-017-01575-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nadine Ait-Bouziad Guohua Lv Anne-Laure Mahul-Mellier Shifeng Xiao Gizem Zorludemir David Eliezer Thomas Walz Hilal A. Lashuel
spellingShingle	Nadine Ait-Bouziad Guohua Lv Anne-Laure Mahul-Mellier Shifeng Xiao Gizem Zorludemir David Eliezer Thomas Walz Hilal A. Lashuel Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes Nature Communications
author_facet	Nadine Ait-Bouziad Guohua Lv Anne-Laure Mahul-Mellier Shifeng Xiao Gizem Zorludemir David Eliezer Thomas Walz Hilal A. Lashuel
author_sort	Nadine Ait-Bouziad
title	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_short	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_full	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_fullStr	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_full_unstemmed	Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
title_sort	discovery and characterization of stable and toxic tau/phospholipid oligomeric complexes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.
url	https://doi.org/10.1038/s41467-017-01575-4
work_keys_str_mv	AT nadineaitbouziad discoveryandcharacterizationofstableandtoxictauphospholipidoligomericcomplexes AT guohualv discoveryandcharacterizationofstableandtoxictauphospholipidoligomericcomplexes AT annelauremahulmellier discoveryandcharacterizationofstableandtoxictauphospholipidoligomericcomplexes AT shifengxiao discoveryandcharacterizationofstableandtoxictauphospholipidoligomericcomplexes AT gizemzorludemir discoveryandcharacterizationofstableandtoxictauphospholipidoligomericcomplexes AT davideliezer discoveryandcharacterizationofstableandtoxictauphospholipidoligomericcomplexes AT thomaswalz discoveryandcharacterizationofstableandtoxictauphospholipidoligomericcomplexes AT hilalalashuel discoveryandcharacterizationofstableandtoxictauphospholipidoligomericcomplexes
_version_	1721451551107579904

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

Similar Items