Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.

Bibliographic Details
Main Authors: Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A. Lashuel
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01575-4