miR-34a promotes bone regeneration in irradiated bone defects by enhancing osteoblastic differentiation of mesenchymal stromal cells in rats

miR-34a promotes bone regeneration in irradiated bone defects by enhancing osteoblastic differentiation of mesenchymal stromal cells in rats

Abstract Background Radiation exposure negatively affects the regenerative ability and makes reconstruction of bone defects after tumor section difficult. miR-34a is involved in radiation biology and bone metabolism. The aim of this study was to investigate whether miR-34a could contribute to bone r...

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Bibliographic Details
Main Authors: Huan Liu, Yan Dong, Xiaoke Feng, Liya Li, Yang Jiao, Shizhu Bai, Zhihong Feng, Hao Yu, Xuejian Li, Yimin Zhao
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Stem Cell Research & Therapy
Subjects:
miR-34a
Bone marrow mesenchymal stromal cell
Bone regeneration
Osteoblastic differentiation
Radiotherapy
Online Access:http://link.springer.com/article/10.1186/s13287-019-1285-y

Internet

http://link.springer.com/article/10.1186/s13287-019-1285-y

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