Exendin-4 Alleviates High Glucose-Induced Rat Mesangial Cell Dysfunction through the AMPK Pathway

Background/Aims: Glucagon-like peptide-1 (GLP-1), which counteracts insulin resistance in humans with type 2 diabetes, has been shown to ameliorate diabetic nephropathy in experimental models. However, the mechanisms through which GLP-1 modulates renal function remained illdefined. The present study...

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Bibliographic Details
Main Authors: Wen-Wei Xu, Mei-Ping Guan, Zong-Ji Zheng, Fang Gao, Yan-Mei Zeng, Yan Qin, Yao-Ming Xue
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
ERK
Online Access:http://www.karger.com/Article/FullText/358623