Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds

Various biological factors have been implicated in convulsive seizures, involving side effects of drugs. For the preclinical safety assessment of drug development, it is difficult to predict seizure-inducing side effects. Here, we introduced a machine learning-based in vitro system designed to detec...

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Bibliographic Details
Main Authors: Mengxuan Gao, Hideyoshi Igata, Aoi Takeuchi, Kaoru Sato, Yuji Ikegaya
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131730004X