Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.

Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.

We describe the successful application of a novel approach for generating dimeric Myc inhibitors by modifying and reversibly linking two previously described small molecules. We synthesized two directed libraries of monomers, each comprised of a ligand, a connector, and a bioorthogonal linker elemen...

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Bibliographic Details
Main Authors: Jutta Wanner, Darlene Romashko, Douglas S Werner, Earl W May, Yue Peng, Ryan Schulz, Kenneth W Foreman, Suzanne Russo, Lee D Arnold, Maneesh Pingle, Donald E Bergstrom, Francis Barany, Stuart Thomson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4398458?pdf=render

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http://europepmc.org/articles/PMC4398458?pdf=render

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