Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer preventive and therapeutic effects of metformin, one of the most widely...

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Bibliographic Details
Main Authors: Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li, Liankang Sun, Cancan Zhou, Luping Gao, Meng Lei, Bin Yan, Junyu Cao, Wanxing Duan, Qingyong Ma
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Cancer
Subjects:
Metformin
Pancreatic cancer
Tumorigenesis
Chronic pancreatitis
Online Access:http://link.springer.com/article/10.1186/s12943-017-0701-0

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http://link.springer.com/article/10.1186/s12943-017-0701-0

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