The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells

The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) remains clinically challenging as effective targeted therapies are lacking. In addition, patient mortality mainly results from the metastasized lesions. CXCR4 has been identified to be one of the major chemokine receptors involved in breast cancer metastasis. Pre...

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Bibliographic Details
Main Authors: Cory M. Howard, Nicole Bearss, Boopathi Subramaniyan, Augustus Tilley, Sangita Sridharan, Nancy Villa, Christopher S. Fraser, Dayanidhi Raman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
CXCR4
LASP1
eIF4F
eIF4A1
eIF4B
breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00284/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00284/full

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