GPR30 Activation by 17β-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor α Protein Expression by Inducing Its Release from a Complex Formed with KEAP1

GPR30 Activation by 17β-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor α Protein Expression by Inducing Its Release from a Complex Formed with KEAP1

Estrogens can elicit rapid cellular responses via the G-protein-coupled receptor 30 (GPR30), followed by estrogen receptor α (ERα/ESR1)-mediated genomic effects. Here, we investigated whether rapid estrogen signaling via GRP30 may affect ESR1 expression, and we examined the underlying molecular mech...

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Bibliographic Details
Main Authors: Chia-Lung Tsai, Chiao-Yun Lin, Angel Chao, Yun-Shien Lee, Ren-Chin Wu, Chi-Neu Tsai, Chih-Feng Yen, An-Shine Chao
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Personalized Medicine
Subjects:
p62
ESR1
KEAP1
endometrial cells
Online Access:https://www.mdpi.com/2075-4426/11/9/906

Internet

https://www.mdpi.com/2075-4426/11/9/906

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