Hyperinsulinaemia down-regulates TLR4 expression in the mammalian heart

Hyperinsulinaemia down-regulates TLR4 expression in the mammalian heart

Toll-like receptors (TLR) are key regulators of innate immune and inflammatory responses and their activation is linked to impaired glucose metabolism during metabolic disease. Determination of whether TLR4 signalling can be activated in the heart by insulin may shed light on the pathogenesis of dia...

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Bibliographic Details
Main Authors: Melody ede Laat, Kaylynn eGruntmeir, Chris ePollitt, Catherine eMcGowan, Martin eSillence, Veronique eLacombe
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Endocrinology
Subjects:
Cytokines
Insulin
Myocardium
Toll-Like Receptor 4
Clamp technique
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00120/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00120/full

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