Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons.

Norepinephrine, a neuromodulator that activates β-adrenergic receptors (βARs), facilitates learning and memory as well as the induction of synaptic plasticity in the hippocampus. Several forms of long-term potentiation (LTP) at the Schaffer collateral CA1 synapse require stimulation of both βARs and...

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Bibliographic Details
Main Authors: Andrew Chay, Ilaria Zamparo, Andreas Koschinski, Manuela Zaccolo, Kim T Blackwell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1004735