Improved cytokine–receptor interaction prediction by exploiting the negative sample space

Improved cytokine–receptor interaction prediction by exploiting the negative sample space

Abstract Background Cytokines act by binding to specific receptors in the plasma membrane of target cells. Knowledge of cytokine–receptor interaction (CRI) is very important for understanding the pathogenesis of various human diseases—notably autoimmune, inflammatory and infectious diseases—and iden...

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Bibliographic Details
Main Authors: Abhigyan Nath, André Leier
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Bioinformatics
Subjects:
Cytokine–receptor interaction
Negative sample space
Deep autoencoders
Random forest
K-means
Online Access:http://link.springer.com/article/10.1186/s12859-020-03835-5

Internet

http://link.springer.com/article/10.1186/s12859-020-03835-5

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