Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Native GABAA receptors are heteromeric assemblies sensitive to many important drugs, from sedatives to anesthetics...

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Bibliographic Details
Main Authors: Swastik Phulera, Hongtao Zhu, Jie Yu, Derek P Claxton, Nate Yoder, Craig Yoshioka, Eric Gouaux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
neurotransmission
GABA receptors
cryo-electron microscopy
GABA
Cys loop receptors
ion channel
Online Access:https://elifesciences.org/articles/39383

Internet

https://elifesciences.org/articles/39383

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