Small angle X-ray scattering and molecular dynamic simulations provide molecular insight for stability of recombinant human transferrin

Transferrin is an attractive candidate for drug delivery due to its ability to cross the blood brain barrier. However, in order to be able to use it for therapeutic purposes, it is important to investigate how its stability depends on different formulation conditions. Combining high-throughput therm...

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Bibliographic Details
Main Authors: Alina Kulakova, Sowmya Indrakumar, Pernille Sønderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang Frieß, Günther H.J. Peters, Pernille Harris
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Structural Biology: X
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152419300157