Eradication of unresectable liver metastasis through induction of tumour specific energy depletion

Treatment of liver metastasis in cancer patients is associated with severe side effects. Here, the authors develop nucleus and mitochondria targeted nanoparticles, conjugated via a cathepsin B sensitive peptide to selectively target liver metastatic cells.

Bibliographic Details
Main Authors:	Da Huo, Jianfeng Zhu, Guojun Chen, Qian Chen, Chao Zhang, Xingyu Luo, Wei Jiang, Xiqun Jiang, Zhen Gu, Yong Hu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11082-3

id	doaj-a92508a4c97a4fc79acc2c38b0b3d30e
record_format	Article
spelling	doaj-a92508a4c97a4fc79acc2c38b0b3d30e2021-05-11T12:41:06ZengNature Publishing GroupNature Communications2041-17232019-07-0110111710.1038/s41467-019-11082-3Eradication of unresectable liver metastasis through induction of tumour specific energy depletionDa Huo0Jianfeng Zhu1Guojun Chen2Qian Chen3Chao Zhang4Xingyu Luo5Wei Jiang6Xiqun Jiang7Zhen Gu8Yong Hu9Collaborative Innovation Center of Chemistry for Life Sciences, College of Engineering and Applied Sciences, Nanjing UniversityCollaborative Innovation Center of Chemistry for Life Sciences, College of Engineering and Applied Sciences, Nanjing UniversityDepartment of Bioengineering and the California Nanosystems Institute, University of CaliforniaDepartment of Bioengineering and the California Nanosystems Institute, University of CaliforniaCollaborative Innovation Center of Chemistry for Life Sciences, College of Engineering and Applied Sciences, Nanjing UniversityCollaborative Innovation Center of Chemistry for Life Sciences, College of Engineering and Applied Sciences, Nanjing UniversityCollaborative Innovation Center of Chemistry for Life Sciences, College of Engineering and Applied Sciences, Nanjing UniversityDepartment of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing UniversityDepartment of Bioengineering and the California Nanosystems Institute, University of CaliforniaCollaborative Innovation Center of Chemistry for Life Sciences, College of Engineering and Applied Sciences, Nanjing UniversityTreatment of liver metastasis in cancer patients is associated with severe side effects. Here, the authors develop nucleus and mitochondria targeted nanoparticles, conjugated via a cathepsin B sensitive peptide to selectively target liver metastatic cells.https://doi.org/10.1038/s41467-019-11082-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Da Huo Jianfeng Zhu Guojun Chen Qian Chen Chao Zhang Xingyu Luo Wei Jiang Xiqun Jiang Zhen Gu Yong Hu
spellingShingle	Da Huo Jianfeng Zhu Guojun Chen Qian Chen Chao Zhang Xingyu Luo Wei Jiang Xiqun Jiang Zhen Gu Yong Hu Eradication of unresectable liver metastasis through induction of tumour specific energy depletion Nature Communications
author_facet	Da Huo Jianfeng Zhu Guojun Chen Qian Chen Chao Zhang Xingyu Luo Wei Jiang Xiqun Jiang Zhen Gu Yong Hu
author_sort	Da Huo
title	Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
title_short	Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
title_full	Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
title_fullStr	Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
title_full_unstemmed	Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
title_sort	eradication of unresectable liver metastasis through induction of tumour specific energy depletion
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Treatment of liver metastasis in cancer patients is associated with severe side effects. Here, the authors develop nucleus and mitochondria targeted nanoparticles, conjugated via a cathepsin B sensitive peptide to selectively target liver metastatic cells.
url	https://doi.org/10.1038/s41467-019-11082-3
work_keys_str_mv	AT dahuo eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT jianfengzhu eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT guojunchen eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT qianchen eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT chaozhang eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT xingyuluo eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT weijiang eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT xiqunjiang eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT zhengu eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion AT yonghu eradicationofunresectablelivermetastasisthroughinductionoftumourspecificenergydepletion
_version_	1721444394890952704

Eradication of unresectable liver metastasis through induction of tumour specific energy depletion

Similar Items