DNA damage and pathway-focused gene expression profiling in the heart of F344 rats exposed to doxorubicin
Doxorubicin (DOX) is an antineoplastic drug effective against many human malignancies. DOX’s clinical efficacy is greatly limited because of severe cardiotoxicity. To evaluate if DOX is genotoxic in the heart, approximately 7- week-old, male F344 rats were administered intravenously 1, 2 and 3 mg/kg...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Genetics |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/conf.fgene.2015.01.00053/full |